| Bioactivity | 2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure. | ||||||||||||
| Name | 2R,4S-Sacubitril | ||||||||||||
| CAS | 761373-05-1 | ||||||||||||
| Formula | C24H29NO5 | ||||||||||||
| Molar Mass | 411.49 | ||||||||||||
| Appearance | Oil | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9. |
2R,4S-Sacubitril
CAS: 761373-05-1 F: C24H29NO5 W: 411.49
2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in co
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