| Bioactivity | 2MD is an orally active vitamin D analog. 2MD stimulates periosteal bone formation and decreases trabecular bone resorption. Thus 2MD restores trabecular and cortical bone mass and strength. 2MD also regulates intraocular pressure (IOP)-relative genes and reduces IOP in non-human primates[1][2]. |
| In Vivo | 2MD (5 μg/eye; 滴注; 单次剂量) 处理 7-8 小时后，可使食蟹猴同侧眼眼压逐渐降低 20%，对侧眼眼压逐渐降低至 15% 或更低[1]。2MD (0.5-10 ng/kg, 0,1 mL/day; 口服给药; 每天 1 次, 共 16 周) 不仅可以恢复骨小梁和皮质骨质量，还可以通过刺激骨膜表面骨形成和减少骨小梁表面骨吸收，增加大鼠的骨质量和强度[2]。 Animal Model: |
| Name | 2MD |
| CAS | 213250-70-5 |
| Formula | C27H44O3 |
| Molar Mass | 416.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kutuzova GD, et al. 1α,25-Dihydroxyvitamin D(3) and its analog, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D(3) (2MD), suppress intraocular pressure in non-human primates. Arch Biochem Biophys. 2012 Feb 1;518(1):53-60. [2]. Ke HZ, et al. A new vitamin D analog, 2MD, restores trabecular and cortical bone mass and strength in ovariectomized rats with established osteopenia. J Bone Miner Res. 2005 Oct;20(10):1742-55. |