| Bioactivity | 27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells apoptosis. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent[1]. |
| Invitro | 27-TBDMS-4-Dehydrowithaferin A (compound 9b; 48 h) exhibits potent antiproliferative effects on HeLa (IC50=1.7 μM), A-549 (IC50=5.3 μM), MCF-7 (IC50=0.5 μM), and normal Vero cells (IC50=3.1 μM)[1]. 27-TBDMS-4-Dehydrowithaferin A (24 μM; 48 h) activates caspase-3 in HeLa cells[1]. 27-TBDMS-4-Dehydrowithaferin A (8 μM; 1-4 h) with a longer incubation period (2-4 h) leads to apoptosis, effect that was maintained at concentrations of 12 and 16 μM[1]. |
| Name | 27-TBDMS-4-Dehydrowithaferin A |
| CAS | 1214886-31-3 |
| Formula | C34H50O6Si |
| Molar Mass | 582.84 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
27-TBDMS-4-Dehydrowithaferin A
CAS: 1214886-31-3 F: C34H50O6Si W: 582.84
27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.
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