| Bioactivity | 22-SLF is a PROTAC degrader, that degrades FK506-binding protein 12 (FKBP12) with a DC50 of 0.5 µM in a FBXO22 dependent manner. 22-SLF degrades other endogenous proteins, such as BRD4 and EML4-ALK fusion protein.(Pink: Ligand for target protein SLF (HY-114872); Black: Linker (HY-163821); Blue: Ligand for E3 ligase (HY-163826))[1]. |
| Formula | C60H76ClN5O13S |
| Molar Mass | 1142.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Basu AA, et al., A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation. Nat Chem Biol. 2024 Jul 4. |