| Bioactivity | 20-HC-Me-Pyrrolidine is a potent Aster protein inhibitor with IC50s of 0.11 μM, 0.06 μM, and 0.71 μM for Aster-A, Aster-B, and Aster-C, respectively. 20-HC-Me-Pyrrolidine blocks the ability of Asters to bind and transfer cholesterol. 20-HC-Me-Pyrrolidine also inhibits the movement of low-density lipoprotein (LDL) cholesterol to the endoplasmic reticulum (ER)[1]. |
| Name | 20-HC-Me-Pyrrolidine |
| Formula | C28H47NO2 |
| Molar Mass | 429.68 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xu Xiao, et al. Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms.Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2024149118. |