| Bioactivity | 20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA)[1][2]. | ||||||||||||
| Invitro | 20-Deoxyingenol (2.5-10 mM; 24 h) protects chondrocytes against Tert-butyl hydroperoxide solution (TBHP; 100 μM)-induced cell death[2].20-Deoxyingenol (5-10 mM) decreases the TBHP-induced upregulation of apoptosis protein cleaved-caspase3 and the senescence protein p16INK4a in chondrocytes[2].20-Deoxyingenol (2.5-40 mM; 24 h) has no cytotoxic effect on chondrocytes at the concentration less than 10 mM[2].20-Deoxyingenol (10 mM; 24 h) restores autophagy flux in TBHP treated chondrocytes[2].20-Deoxyingenol (4-10 mM; 24 h) promotes the nuclear level of TFEB in TBHP treated chondrocytes[2]. | ||||||||||||
| Name | 20-Deoxyingenol | ||||||||||||
| CAS | 54706-99-9 | ||||||||||||
| Formula | C20H28O4 | ||||||||||||
| Molar Mass | 332.43 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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20-Deoxyingenol
CAS: 54706-99-9 F: C20H28O4 W: 332.43
20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and
Data collection：peptidedb@qq.com
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