| Bioactivity | 20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 20-(tert-Butoxy)-20-oxoicosanoic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs| Invitro |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
Name |
20-(tert-Butoxy)-20-oxoicosanoic acid |
CAS |
683239-16-9 |
Formula |
C24H46O4 |
Molar Mass |
398.62 |
Transport |
Room temperature in continental US; may vary elsewhere. |
Storage |
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20-(tert-Butoxy)-20-oxoicosanoic acid
CAS: 683239-16-9 F: C24H46O4 W: 398.62
20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates
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