2-Thio-UTP_product_DataBase

Bioactivity	2-Thio-UTP is a selective P2Y2 inhibitor with an EC50 value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) [1][2].
Invitro	2-Thio-UTP (10 µM; 5 days) 可降低瓣膜间质细胞中 ACTA2、TGFB1、TGFB2、COL1A1、COL3A1 的 mRNA 表达，并降低 αSMA 的蛋白质[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 2-Thio-UTP 相关抗体: Western Blot Analysis[2] Cell Line:
CAS	35763-29-2
Formula	C9H15N2O14P3S
Molar Mass	500.21
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. El-Tayeb A, et al. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49(24):7076-87. [2]. Moschetta D, et al. Purinergic Receptor P2Y2 Stimulation Averts Aortic Valve Interstitial Cell Calcification and Myofibroblastic Activation. Biomedicines. 2022 Feb 16;10(2):457.

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