| Bioactivity | 2-Linoleoyl glycerol (2-Monolinolein; 2-Monolinoleoylglycerol) is a monoacylglycerol that is an antagonist and partial agonist at the type 1 cannabinoid CB1 receptor. The potency of 2-Linoleoyl glycerol can be enhanced by JZL195 (HY-15250), an inhibitor of FAAH and MAGL, and inhibited by the CB1 antagonist AM251 (HY-15443) and Cannabidiol. As a CB1 antagonist, 2-Linoleoyl glycerol does not enhance, but only attenuates, the activity of the CB1/CB2 receptor ligands cannabinoids (AEA) and 2-arachidonoylglycerol (2-AG)[1][2]. |
| Target | CB1 |
| CAS | 3443-82-1 |
| Formula | C21H38O4 |
| Molar Mass | 354.52 |
| Appearance | 液体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Solution, -20°C, 2 years |
| Reference | [1]. Lu L, et al. 2-Linoleoylglycerol is a partial agonist of the human cannabinoid type 1 receptor that can suppress 2-arachidonolyglycerol and anandamide activity[J]. Cannabis and cannabinoid research, 2019, 4(4): 231-239. [2]. Sugiura T, et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma× glioma hybrid NG108-15 cells[J]. Biochemical and biophysical research communications, 1996, 229(1): 58-64. |
2-Linoleoyl glycerol
CAS: 3443-82-1 F: C21H38O4 W: 354.52
2-Linoleoyl glycerol (2-Monolinolein; 2-Monolinoleoylglycerol) is a monoacylglycerol that is an antagonist and partial a
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.