| Bioactivity | Hydroxyisoquinoline-1,3(2H,4H)-dione (compound 6a) is a HIV-1 integrase (IN) and HIV-1 reverse transcriptase (RT) ribonuclease H (RNase H) inhibitor with an IC50 value of 6.32, 5.9 µM, respectively[1]. |
| Target | IC50: 6.32 µM (HIV-1 IN); 5.9 µM (HIV-1 RT RNase H) |
| CAS | 6890-08-0 |
| Formula | C9H7NO3 |
| Molar Mass | 177.16 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Billamboz M, et al. Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain. J Med Chem. 2008 Dec 25;51(24):7717-30. |
2-Hydroxyisoquinoline-1,3(2H,4H)-dione
CAS: 6890-08-0 F: C9H7NO3 W: 177.16
Hydroxyisoquinoline-1,3(2H,4H)-dione (compound 6a) is a HIV-1 integrase (IN) and HIV-1 reverse transcriptase (RT) ribonu
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