2'-Deoxyguanosine 5'-monophosphate disodium hydrate_product_DataBase

Bioactivity	2'-Deoxyguanosine 5'-monophosphate (5'-Deoxyguanylic acid; dGMP) disodium hydrate is an oxidizable target of the photosensitizer pterin (PT) and can be used to evaluate the photosensitizing properties of biopterins (such as Bip, Fop and Cap) . Pterin causes a photosensitive reaction of dGMP under UV-A radiation, causing damage to DNA molecules. There are two main mechanisms for the photosensitive oxidation of purine nucleotides by pterin in vitro: one is the hydrogen abstraction reaction of electron transfer from dGMP to the triplet excited state of pterin (type I mechanism), and the other is the interaction between dGMP and pterin. The reaction produces singlet molecular oxygen (1O2) (Type II mechanism)[1][2].
CAS	146877-98-7
Formula	C10H14N5O7.H2O.2Na
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Petroselli G, Dántola M L, Cabrerizo F M, et al. Oxidation of 2 ‘-Deoxyguanosine 5 ‘-Monophosphate Photoinduced by Pterin: Type I versus Type II Mechanism[J]. Journal of the American Chemical Society, 2008, 130(10): 3001-3011. [2]. Song B, Sigel H. Metal Ion-Coordinating Properties of 2 ‘-Deoxyguanosine 5 ‘-Monophosphate (dGMP2-) 1 in Aqueous Solution. Quantification of Macrochelate Formation[J]. Inorganic Chemistry, 1998, 37(8): 2066-2069.

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