Bioactivity | 2-Deoxy-L-ribose is a stereoisomer of 2-Deoxy-d-ribose that inhibits 2-Deoxy-d-ribose anti-apoptotic effects. 2-Deoxy-L-ribose suppresses metastasis of tumor cells overexpressing thymidine phosphorylase[1]. |
Invitro | 2-Deoxy-L-ribose(10-100 μM;24 小时)显著减少缺氧条件下侵袭 KB/TP 细胞的数量[1]。2-Deoxy-L-ribose(10-100 μM;48 小时)降低缺氧条件下 KB/TP 细胞中的 VEGF 和 IL-8 mRNA 水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 2-Deoxy-L-ribose 相关抗体: Cell Invasion Assay[1] Cell Line: |
In Vivo | 2-Deoxy-L-ribose(20-100 mg/kg;口服;每日;28 天)可减少肝转移结节和转移面积,抑制血管生成,促进细胞凋亡[1]。2-Deoxy-L-ribose(20 mg/kg;口服;每日;52 天)在减少腹部转移结节方面比 Tegafur (HY-17400) (100 mg/kg) 效果更佳[1]。。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
CAS | 18546-37-7 |
Formula | C5H10O4 |
Molar Mass | 134.13 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Nakajima Y, et al. Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-ribose. Cancer Res. 2004 Mar 1;64(5):1794-801. |