2-Deoxy-D-glucose 6-phosphate_product_DataBase

Bioactivity	2-Deoxy-D-glucose 6-phosphate is an intermediate of 2-deoxy-D-glucose (2-DG) [1]. 2-Deoxy-D-glucose is incorporated into glycogen[2].
Invitro	Acting as a D-glucose mimic, 2-deoxy-D-glucose (2-DG) inhibits glycolysis due to formation and intracellular accumulation of 2-deoxy-D-glucose-6-phosphate (2-DG6P), inhibiting the function of hexokinase and glucose-6-phosphate isomerase, and inducing cell death[3].The accumulation of 2-deoxyglucose-6-phosphate (2-DG6P), detected using 31P nuclear magnetic resonance spectroscopy, is used to assess glucose uptake before and during insulin stimulation in the isolated perfused heart[4].
Name	2-Deoxy-D-glucose 6-phosphate
CAS	3573-50-0
Formula	C6H13O8P
Molar Mass	244.14
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kuo SC, et al. Inhibition by 2-deoxy-D-glucose of synthesis of glycoprotein enzymes by protoplasts of Saccharomyces: relation to inhibition of sugar uptake and metabolism. J Bacteriol. 1972;111(2):419-429. [2]. Doenst T, et al. Complexities underlying the quantitative determination of myocardial glucose uptake with 2-deoxyglucose. J Mol Cell Cardiol. 1998;30(8):1595-1604. [3]. Pajak B, et al. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents. Int J Mol Sci. 2019;21(1):234. Published 2019 Dec 29. [4]. Paternostro G, et al. Decreased GLUT-4 mRNA content and insulin-sensitive deoxyglucose uptake show insulin resistance in the hypertensive rat heart. Cardiovasc Res. 1995;30(2):205-211.

PeptideDB

2-Deoxy-D-glucose 6-phosphate

CAS: 3573-50-0 F: C6H13O8P W: 244.14