2-Cyanopyrimidine_product_DataBase

CAS: 14080-23-0 F: C5H3N3 W: 105.10

2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanop

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity

2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos[1].

Target

IC50: 170 nM (cysteine protease cathepsin K)

Invitro

2-Cyanopyrimidine is a 2-cyano-4-cyclohexylamino-pyrimidine derivative. Cathepsin K is a lysosomal cysteine protease[1].

Name

2-Cyanopyrimidine

CAS

14080-23-0

Formula

C5H3N3

Molar Mass

105.10

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Altmann E, et al. 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem. 2007 Feb 22;50(4):591-4.

PeptideDB

2-Cyanopyrimidine

CAS: 14080-23-0 F: C5H3N3 W: 105.10