2,4-Difluorophenylethynylcobalamin_product_DataBase

CAS: 2101750-19-8 F: C70H91CoF2N13O14P W: 1466.45

2,4-Difluorophenylethynylcobalamin is a potential B12 antivitamin via binding to human B12 -processing enzyme CblC with

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Bioactivity	2,4-Difluorophenylethynylcobalamin is a potential B12 antivitamin via binding to human B12 -processing enzyme CblC with high affinity (KD=130 nm). 2,4-Difluorophenylethynylcobalamin withstood tailoring by CblC, and stabilizes the ternary complex with the cosubstrate glutathione (GSH)[1].
Target	B12 -processing enzyme CblC
Name	2,4-Difluorophenylethynylcobalamin
CAS	2101750-19-8
Formula	C70H91CoF2N13O14P
Molar Mass	1466.45
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reference	[1]. Ruetz M, et al. Antivitamin B12 Inhibition of the Human B12 -Processing Enzyme CblC: Crystal Structure of an Inactive Ternary Complex with Glutathione as the Cosubstrate. Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7387-7392.

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