| Bioactivity | 19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC50 value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels[1]. |
| Invitro | 19(S)-HETE (1 μM; 15 min) 剂量依赖性诱导 cAMP 在 MEG-01 细胞中增加，EC50 值为 520 nM[1]。19(S)-HETE (1 μM-1 M) 剂量依赖性地激活环前列腺素受体，EC50 值为 567 nM[1]。19(S)-HETE (10 μM-1 M) 取代 3H-iloprost，在表达的环前列腺素受体的 COS-1 细胞，Ki 值为 660 nM[1]。19(S)-HETE (3 μM) 可松弛动脉血管，抑制血小板活化[1]。 |
| Name | 19(S)-HETE |
| CAS | 115461-40-0 |
| Formula | C20H32O3 |
| Molar Mass | 320.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tunaru S, et al. Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor. PLoS One. 2016 Sep 23;11(9):e0163633. |