| Bioactivity | 187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein[1][2]. | ||||||
| Name | 187-1, N-WASP inhibitor | ||||||
| CAS | 380488-27-7 | ||||||
| Sequence | Cyclo[Gln-Lys-{d-Phe}-{d-Pro}-{d-Phe}-Phe-{d-Pro}-Gln-Lys-{d-Phe}-{d-Pro}-{d-Phe}-Phe-{d-Pro}] | ||||||
| Shortening | Cyclo[QK-{d-Phe}-{d-Pro}-{d-Phe}-F-{d-Pro}-QK-{d-Phe}-{d-Pro}-{d-Phe}-F-{d-Pro}] | ||||||
| Formula | C96H122N18O16 | ||||||
| Molar Mass | 1784.11 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
187-1, N-WASP inhibitor
CAS: 380488-27-7 F: C96H122N18O16 W: 1784.11
187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhib
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