| Bioactivity | 18-Deoxyherboxidiene (RQN-18690A) is a potent angiogenesis inhibitor. 18-Deoxyherboxidiene targets SF3b, a spliceosome component that is a subcomplex of the U2 small nuclear ribonucleoprotein (snRNP) in the spliceosome. 18-Deoxyherboxidiene inhibits the migration and tube formation of human umbilical vein endothelial cells (HUVECs) without significant cell toxicity. 18-Deoxyherboxidiene has the potential for cancer research[1]. |
| Name | 18-Deoxyherboxidiene |
| CAS | 1200128-66-0 |
| Formula | C25H42O5 |
| Molar Mass | 422.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hideaki Kakeya, et al. RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis. J Antibiot (Tokyo). 2016 Feb;69(2):121-3. |
18-Deoxyherboxidiene
CAS: 1200128-66-0 F: C25H42O5 W: 422.60
18-Deoxyherboxidiene (RQN-18690A) is a potent angiogenesis inhibitor. 18-Deoxyherboxidiene targets SF3b, a spliceosome c
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