17β-Hydroxywortmannin_product_DataBase

Bioactivity	17β-Hydroxywortmannin is an orally active inhibitor for phosphatidylinositol-3-kinase (PI-3-kinase) with an IC50 of 0.5 nM, suppresses the osteoclast resorption with an IC50 of 10 nM[1]. 17β-Hydroxywortmannin exhibits antitumor activity[2].
In Vivo	17β-Hydroxywortmannin (0.1 μg/kg，口服 5 周) 具有促进破骨细胞分化的活性，可以预防去卵巢大鼠由于雌激素缺乏引起的骨质流失[1]。17β-Hydroxywortmannin (2.5 mg/kg/week，静脉注射 2 周) 对 U87MG 胶质瘤具有抗肿瘤活性，在人肿瘤异种移植裸鼠中治疗指数为 26[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	58053-83-1
Formula	C23H26O8
Molar Mass	430.45
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hall TJ, et al., Wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, inhibits osteoclastic bone resorption in vitro. Calcif Tissue Int. 1995 Apr;56(4):336-8. [2]. Zask A, et al., Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy. J Med Chem. 2008 Mar 13;51(5):1319-23.

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