17(R)-Resolvin D1

CAS: 528583-91-7 F: C22H32O5 W: 376.49

17R-Resolvin D1 is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and hum

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Bioactivity	17R-Resolvin D1 is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells[1]. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy[2].
Invitro	17R-Resolvin D1 (0-1000 nM) 剂量依赖性地减少 fMLP 诱导的人多形核白细胞 (PMN) 的跨内皮迁移，发挥抗急性炎症的作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 17(R)-Resolvin D1 相关抗体: Cell Migration Assay [1] Cell Line:
In Vivo	17R-Resolvin D1 (0.05-50 μg/kg，静脉注射) 减少 FVB 小鼠体内的 PMN 细胞浸润，在 100 ng/kg 剂量时达到最大抑制浓度，一直比例为 35%[1]。17R-Resolvin D1 (30 µM in 20 µL，皮内注射) TRPV3 特异性地减轻 ICR 小鼠体内由 CFA 诱导的急性疼痛[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	528583-91-7
Formula	C22H32O5
Molar Mass	376.49
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Sun YP, et al., Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem. 2007 Mar 30;282(13):9323-9334. [2]. Bang S, et al., 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br J Pharmacol. 2012 Feb;165(3):683-92.