| Bioactivity | 155H1 (Compound 11) is a stapled peptide, that covalently binds hMcl1 (172-323) with IC50 of 18 nM[1]. |
| Sequence | Ac-{Dap(2MeO,5FSB)}-Ile-Ala-Glu-Gln-Leu-Arg-{(S)-2-(4-pentenyl)Ala}-Ile-Gly-Asp-{(S)-2-(4-pentenyl)Ala}-Phe-CONH2 (2MeO,5FSB=2-methoxy, 5-sulfonyl fluoride) |
| Shortening | Ac-{Dap(2MeO,5FSB)}-IAEQLR-{(S)-2-(4-pentenyl)Ala}-IGD-{(S)-2-(4-pentenyl)Ala}-F-CONH2 (2MeO,5FSB=2-methoxy, 5-sulfonyl fluoride) |
| Formula | C79H120FN19O23S |
| Molar Mass | 1754.98 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Alboreggia G, et al., Histidine-Covalent Stapled Alpha-Helical Peptides Targeting hMcl-1. J Med Chem. 2024 May 23;67(10):8172-8185. |