| Bioactivity | 15(R)-15-Methyl Prostaglandin F2α (15(R)-Carboprost; 15(R)-15-methyl PGF2α) is a metabolically stable analog of PGF2α. 15(R)-15-Methyl Prostaglandin F2α is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15(R)-15-Methyl Prostaglandin F2α converts it into the active 15(S)-isomer. The 15(S)-isomer induces luteolysis when injected in rhesus monkeys at a dose of about 12 mg/animal, while the 15(R)-isomer does not. |
| CAS | 35864-81-4 |
| Formula | C21H36O5 |
| Molar Mass | 368.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hamberg, et al. On the pH-dependent degradation of 15(S)-15 methyl-prostaglandin F2α (Carboprost). Eur. J. Pharm. Sci. 3(1), 27-38 (1995). |
15(R)-15-Methyl Prostaglandin F2α
CAS: 35864-81-4 F: C21H36O5 W: 368.51
15(R)-15-Methyl Prostaglandin F2α (15(R)-Carboprost; 15(R)-15-methyl PGF2α) is a metabolically stable analog of PGF2α
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