| Bioactivity | 12-Oxo-leukotriene B4 (12-Oxo-LTB4) is an intermediate in the lipoxygenase-catalyzed path of Arachidonic acid (HY-109590) metabolism. 12-Oxo-leukotriene B4 is crucial in Leukotriene B4 metabolism and is involved in inflammation reactions[1]. 12-Oxo-leukotriene B4 stimulates calcium levels in human neutrophils with an EC50 of 33 nM. 12-Oxo-leukotriene B4 induces migration of neutrophils with EC50 of 170 nM[2]. |
| CAS | 136696-10-1 |
| Formula | C20H30O4 |
| Molar Mass | 334.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Khanapure S P, et al., 12-Oxo-LTB4, a key pivotal intermediate in LTB4 metabolism[J]. The Journal of Organic Chemistry, 1995, 60(6): 1806-1813. [2]. Powell WS, et al., Effects of metabolites of leukotriene B4 on human neutrophil migration and cytosolic calcium levels. J Pharmacol Exp Ther. 1996 Feb;276(2):728-36. |
12-Oxo-leukotriene B4
CAS: 136696-10-1 F: C20H30O4 W: 334.45
12-Oxo-leukotriene B4 (12-Oxo-LTB4) is an intermediate in the lipoxygenase-catalyzed path of Arachidonic acid (HY-109590
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