| Bioactivity | 12-Deoxyphorbol 13-palmitate is a traditional Chinese medicine monomer with antitumor activity that can be isolated from the root of Euphorbia fischeriana. 12-Deoxyphorbol 13-palmitate induces gastric cancer cell cycle arrest and apoptosis by regulating key cell cycle regulators such as cyclin B、cyclin A and CDC2. In addition, 12-Deoxyphorbol 13-palmitate can significantly weaken APOL2–SERCA2–PERK–HES1 signaling and slow liver fibrosis by targeting APOL2[1][2]. |
| CAS | 66583-59-3 |
| Formula | C36H58O6 |
| Molar Mass | 586.84 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. HuiYu Xu, et al. "12-Deoxyphorbol 13-palmitate mediated cell growth inhibition, G2-M cell cycle arrest and apoptosis in BGC823 cells." European journal of pharmacology 700.1-3 (2013): 13-22. [2]. Lu Gan, et al. "A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2." Nature Chemical Biology (2024): 1-11. |
12-Deoxyphorbol 13-palmitate
CAS: 66583-59-3 F: C36H58O6 W: 586.84
12-Deoxyphorbol 13-palmitate is a traditional Chinese medicine monomer with antitumor activity that can be isolated from
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