| Bioactivity | 12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release[1][2]. |
| Target | Ca2+-activated K+ (BK) channelGABAA |
| Name | 12,14-Dichlorodehydroabietic acid |
| CAS | 65281-77-8 |
| Formula | C20H26Cl2O2 |
| Molar Mass | 369.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. R A Nicholson, et al. Inhibition of GABA-gated chloride channels by 12,14-dichlorodehydroabietic acid in mammalian brain. Br J Pharmacol. 1999 Mar;126(5):1123-32. [2]. Kazuho Sakamoto, et al. Molecular mechanisms for large conductance Ca2+-activated K+ channel activation by a novel opener, 12,14-dichlorodehydroabietic acid. J Pharmacol Exp Ther. 2006 Jan;316(1):144-53. |
12,14-Dichlorodehydroabietic acid
CAS: 65281-77-8 F: C20H26Cl2O2 W: 369.33
12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Di
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