| Bioactivity | 11β-HSD1-IN-8 (compound c6a) is a 11β‑HSD1 inhibitor with an IC50 value of 2.3 μM for human 11β‑HSD1. 11β-HSD1-IN-8 can be used for the research of diabetes and cognitive decline[1]. | ||||||||||||
| Target | IC50: 2.3 μM (human 11β‑HSD) | ||||||||||||
| Invitro | 11β-HSD1-IN-8 (0-50 μM) inhibits human and rat 11β‑HSD1 with IC50 values of 2.3 μM and ＞50 μM, respectively[1]. | ||||||||||||
| Name | 11β-HSD1-IN-8 | ||||||||||||
| CAS | 386704-15-0 | ||||||||||||
| Formula | C10H8F3NO3 | ||||||||||||
| Molar Mass | 247.17 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Naredo-Gonzalez G, et al. Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy. Sci Rep. 2022 Sep 29;12(1):16268. |