| Bioactivity | 116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg)’s endogenous ATPase activity and the TAg-mediated activation of Hsp70[1][2]. | ||||||||||||
| Target | Simian Virus 40 (SV40) Hsp70 co-chaperone DNAJA1 | ||||||||||||
| Invitro | 116-9e (MAL2-11B) inhibits TAg stimulation of Hsp70 with greater efficacy than MAL3-101, significantly reduces viral replication and DNA synthesis. MAL2-11B also inhibits the activity of the TAg ATPase domain[1]. 116-9e (MAL2-11B; 15 µM; 5 days) significantly reduces the growth of BK virus in a human kidney cell line[1]. | ||||||||||||
| Name | 116-9e | ||||||||||||
| CAS | 831217-43-7 | ||||||||||||
| Formula | C31H32N2O5 | ||||||||||||
| Molar Mass | 512.60 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Christine M Wright, et al. Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Res. 2009 Apr;141(1):71-80. [2]. Nitika, et al. Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance. Sci Rep. 2020 Aug 14;10(1):13831. |