| Bioactivity | 10m/ZS44 is a blood-brain barrier-permeable Glioblastoma (GBM) inhibitor. 10m/ZS44 significantly inhibits GBM tumor growth in a mouse xenograft model. 10m/ZS44 also activates the SIRT1/p53-mediated apoptosis pathway, thereby inhibiting the proliferation of U251 cells[1]. |
| Name | 10m/ZS44 |
| Formula | C31H32N2O6 |
| Molar Mass | 528.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhu H, et al. Design, synthesis, and biological evaluation of novel spirocyclic compounds as potential anti-glioblastoma agents. Eur J Med Chem. 2023 Oct 5;258:115595. |