| Bioactivity | 10Panx is a biological active peptide. (This is a Pannexin-1 (Panx1) mimetic blocking peptide. Pannexin-1 is a recently identified membrane protein that can form gap junction-like connections allowing intercellular passage of dyes when overexpressed in two adjacent oocytes or mammalian epithelial cell lines. Blockade of pannexin-1 in macrophage endogenously expressing the ATP-gated P2X7 receptor (P2X7R) blocks the initial dye uptake, but not the ionic current, and also blocks processing and release of interleukin-1b (IL-1b) in response to P2X7R activation.) |
| Name | 10Panx |
| CAS | 955091-53-9 |
| Sequence | Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr |
| Shortening | WRQAAFVDSY |
| Formula | C58H79N15O16 |
| Molar Mass | 1242.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |