| Bioactivity | 1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) sodium, a potent bioactive phospholipid, is a LPA receptor activator. 1-Oleoyl lysophosphatidic acid sodium can promote mitosis by inducing DNA synthesis. 1-Oleoyl lysophosphatidic acid sodium is also involved in normal and pathological emotional responses, including anxiety and depression[1][2][3]. |
| Target | LPA receptor |
| Invitro | 1-Oleoyl lysophosphatidic acid (0.1-10 μM) sodium elicits an acute rise of [Ca2+]i in rat and rabbit osteoclasts[2].1-Oleoyl lysophosphatidic acid (5 μM) sodium induces retraction of osteoclast lamellipodia[2]. |
| Name | 1-Oleoyl lysophosphatidic acid sodium |
| CAS | 325465-93-8 |
| Formula | C21H40NaO7P |
| Molar Mass | 458.50 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Corven EJ, et, al. Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin. Biochem J. 1992 Jan 1;281 ( Pt 1)(Pt 1):163-9. [2]. Lapierre DM, et, al. Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival. J Biol Chem. 2010 Aug 13;285(33):25792-801. [3]. Castilla-Ortega E, et, al. 1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats. PLoS One. 2014 Jan 7;9(1):e85348. |
1-Oleoyl lysophosphatidic acid sodium
CAS: 325465-93-8 F: C21H40NaO7P W: 458.50
1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) sodium, a potent bioactive phospholipid, is a LPA recep
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