| Bioactivity | 1-Isopropyltryptophan (1-IsoPT) is a IDO1 inhibitor. 1-Isopropyltryptophan decreases the expression of IFN-γ stimulated ID0-1 and ID0-2 mRNA[1]. |
| Invitro | 1-Isopropyltryptophan (24 h) 对小鼠 DC 2.4 系具有细胞毒性，IC50 值为 2.156 mM[1]。1-Isopropyltryptophan (100 µM; 48 h) 可降低 DC 2.4 细胞中 IFN-γ (0.5 µg/ml) 刺激的 ID0-1 和 ID0-2 mRNA 的表达[1]。 RT-PCR[1] Cell Line: |
| Name | 1-Isopropyltryptophan |
| CAS | 1219485-46-7 |
| Formula | C14H18N2O2 |
| Molar Mass | 246.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sun T, et al. Novel 1-alkyl-tryptophan derivatives downregulate IDO1 and IDO2 mRNA expression induced by interferon-gamma in dendritic cells. Mol Cell Biochem. 2010 Sep;342(1-2):29-34. |
1-Isopropyltryptophan
CAS: 1219485-46-7 F: C14H18N2O2 W: 246.30
1-Isopropyltryptophan (1-IsoPT) is a IDO1 inhibitor. 1-Isopropyltryptophan decreases the expression of IFN-γ stimulated
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