| Bioactivity | 1-Cinnamoyltrichilinin can inhibit the viability of HL-60 human leukemia cells, induceapoptosis of HL-60 cells, and increase nuclear fragmentation and fractional DNA content by activating the p38 MAPK pathway. The anti-cancer properties of 1-Cinnamoyltrichilinin are only effective against HL-60 cells, not in other human cancer cell lines, such as epidermoidcarcinoma (A431), lung epithelial carcinoma (A549), and mammary gland adenocarcinoma (MCF7),at a 20 µM concentration, which is otherwise not toxic to a normal cell line (RAW 264.7). 1-Cinnamoyltrichilinin can be used in the research of leukemia[1]. |
| CAS | 117869-72-4 |
| Formula | C39H46O9 |
| Molar Mass | 658.78 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jeong H, et al. 1-Cinnamoyltrichilinin from Melia azedarach Causes Apoptosis through the p38 MAPK Pathway in HL-60 Human Leukemia Cells. Int J Mol Sci. 2020 Oct 12;21(20):7506. |
1-Cinnamoyltrichilinin
CAS: 117869-72-4 F: C39H46O9 W: 658.78
1-Cinnamoyltrichilinin can inhibit the viability of HL-60 human leukemia cells, induceapoptosis of HL-60 cells, and incr
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