| Bioactivity | 1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM[1]. | |||||||||
| Invitro | 1,8-Dihydroxy-4,5-dinitroanthraquinone (50 μM-2 mM；90 分钟) 抑制 NS2B/3 裂解，并在 100 μM 时显着且显着地作用于 BHK-21 细胞[1]。 | |||||||||
| Name | 1,8-Dihydroxy-4,5-dinitroanthraquinone | |||||||||
| CAS | 81-55-0 | |||||||||
| Formula | C14H6N2O8 | |||||||||
| Molar Mass | 330.21 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
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| Reference | [1]. Constant DA, et al. Targeting intramolecular proteinase NS2B/3 cleavages for trans-dominant inhibition of dengue virus. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10136-10141. |
1,8-Dihydroxy-4,5-dinitroanthraquinone
CAS: 81-55-0 F: C14H6N2O8 W: 330.21
1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue v
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