1,2,3,4-Tetrahydro Staurosporin_product_DataBase

CAS: 220038-19-7 F: C₂₈H₃₀N₄O₃ W: 470.56

1,2,3,4-Tetrahydrostaurosporine is a derivative of Staurosporine (HY-15141) and an inhibitor of mutant EGFR (IC50=74 nM

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	1,2,3,4-Tetrahydrostaurosporine is a derivative of Staurosporine (HY-15141) and an inhibitor of mutant EGFR (IC50=74 nM for EGFRT790M). It is selective for EGFRT790M over wild-type EGFR (IC50=390 nM). It also binds to Janus kinase 3 (JAK3).
CAS	220038-19-7
Formula	C₂₈H₃₀N₄O₃
Molar Mass	470.56
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Song, et al. Staurosporine scaffold-based rational discovery of the wild-type sparing reversible inhibitors of EGFR T790M gatekeeper mutant in lung cancer with analog-sensitive kinase technology. J. Mol. Recognit. 30(4):e2590,(2017).

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