1,11b-Dihydro-11b-hydroxymedicarpin_product_DataBase

Bioactivity	1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative[1]. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways[2]. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice[3].
Name	1,11b-Dihydro-11b-hydroxymedicarpin
CAS	210537-04-5
Formula	C16H16O5
Molar Mass	288.30
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Alejandro F.Barrero, et al. Pterocarpans from Ononis viscosa subsp. breviflora. Phytochemistry. 1998 May, 48 (1): 187-190. [2]. Manisha Dixit, et al. Medicarpin, a Natural Pterocarpan, Heals Cortical Bone Defect by Activation of Notch and Wnt Canonical Signaling Pathways. PLoS One. 2015 Dec 11;10(12):e0144541. [3]. Mohd Nizam Mansoori, et al. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Int Immunopharmacol. 2020 Feb 22;82:106299.

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