| Bioactivity | 1(R)-(Trifluoromethyl)oleyl alcohol (compound (R)-24) is a trifluoromethyl alcohol derivative of Oleic acid (HY-N1446) with activity in multiple models of Friedreich ataxia (FRDA). 1(R)-(Trifluoromethyl)oleyl alcohol at 40 μM increases survival to 95% in a model of FRDA where there is a larger percentage of cell death caused by FAC (HY-B1645) and BSO (HY-106376). 1(R)-(Trifluoromethyl)oleyl alcohol inhibits ferroptosis induced by Erastin (HY-15763) and decreases lipid peroxidation in NBT human myoblasts with frataxin (FXN) siRNA knockdown[1]. |
| CAS | 2644636-20-2 |
| Formula | C19H35F3O |
| Molar Mass | 336.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. M Grazia Cotticelli, et al. Identification of a Novel Oleic Acid Analog with Protective Effects in Multiple Cellular Models of Friedreich Ataxia. ACS Chem Neurosci. 2020 Sep 2;11(17):2535-2542. |
1(R)-(Trifluoromethyl)oleyl alcohol
CAS: 2644636-20-2 F: C19H35F3O W: 336.48
1(R)-(Trifluoromethyl)oleyl alcohol (compound (R)-24) is a trifluoromethyl alcohol derivative of Oleic acid (HY-N1446) w
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