| Bioactivity | (rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway[1]. |
| Name | (rac)-AG-205 |
| CAS | 442656-02-2 |
| Formula | C22H23ClN6OS |
| Molar Mass | 454.98 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cahill MA. Unde venisti PGRMC? Grand-Scale Biology from Early Eukaryotes and Eumetazoan Animal Origins. Front Biosci (Landmark Ed). 2022 Nov 30;27(11):317 |
(rac)-AG-205
CAS: 442656-02-2 F: C22H23ClN6OS W: 454.98
(rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in
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