| Bioactivity | (p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats[1]. |
| Invitro | (p-Iodo-Phe7)-ACTH (4-10) (1 μM) exhibits inhibition of α-MSH-induced (1 nM-1 μM) cAMP accumulation in 293 HEK cells expressing either the rat melanocortin MC3, human melanocortin MC4 or ovine melanocortin MC5 receptor[1].[Phe-I7]ACTH(4-10) has higher affinity for the MC3, MC4, and MC5 receptors but lower for the MC1 compared to ACTH(4-10)[2]. |
| Name | (p-Iodo-Phe7)-ACTH (4-10) |
| CAS | 159600-82-5 |
| Shortening | MEH-{p-Iodo-Phe}-RWG |
| Formula | C44H58IN13O10S |
| Molar Mass | 1087.98 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
(p-Iodo-Phe7)-ACTH (4-10)
CAS: 159600-82-5 F: C44H58IN13O10S W: 1087.98
(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the ant
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