Bioactivity | (aS)-PH-797804 is a selective p38 MAPK inhibitor with IC50 values for p38 α /β of 26 and 102 nM, respectively. (aS)-PH-797804 has anti-inflammatory activity[1][2]. |
Name | (aS)-PH-797804 |
CAS | 1358027-80-1 |
Formula | C22H19BrF2N2O3 |
Molar Mass | 477.30 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Hope HR, et al. Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation. J Pharmacol Exp Ther. 2009 Dec;331(3):882-95. [2]. Selness SR, et al. Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4066-71. |