| Bioactivity | (Z)-Tyrphostin A51 is the Z configuration of Lanoconazole A51. Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [3H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation[1][2]. |
| Name | (Z)-Tyrphostin A51 |
| CAS | 122520-90-5 |
| Formula | C13H8N4O3 |
| Molar Mass | 268.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Alexander A. et al. [3H]taurine andd-[3H]aspartate release from astrocyte cultures are differently regulated by tyrosine kinases. Physiology-cell physiology. 1999, 1226-1230. [2]. Yoon HK, et al. Differential effects of two protein tyrosine kinase inhibitors, tyrphostin and genistein, on human bone cell proliferation as compared with differentiation. Calcif Tissue Int. 1998 Sep;63(3):243-9. |
(Z)-Tyrphostin A51
CAS: 122520-90-5 F: C13H8N4O3 W: 268.23
(Z)-Tyrphostin A51 is the Z configuration of Lanoconazole A51. Tyrphostin A51 is a potent protein tyrosine kinase (PTK)
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