| Bioactivity | (Z)-RG-13022 is a tyrosine kinase (TK) inhibitor, which inhibits preferentially the TK activity of the EGF receptor and inhibits EGF-stimulated growth of cultured cells. (Z)-RG-13022 exerts an IC50 of 11 μM for DNA synthesis in the HN5 cells, which is 3 times more potent than (E)-RG-13022 (IC50=38 μM). (Z)-RG-13022 can be used for research of breast cancer cells[1][2]. |
| Invitro | (Z)-RG-13022 (1-100 μM, 24 h) 剂量依赖性地抑制 HN5 细胞的 DNA 合成，且不影响细胞活力[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> (Z)-RG-13022 相关抗体: |
| CAS | 149286-90-8 |
| Formula | C16H14N2O2 |
| Molar Mass | 266.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Reddy KB, et al. Inhibition of breast cancer cell growth in vitro by a tyrosine kinase inhibitor. Cancer Res. 1992 Jul 1;52(13):3636-41. [2]. McLeod HL, et al. In vivo pharmacology and anti-tumour evaluation of the tyrphostin tyrosine kinase inhibitor RG13022. Br J Cancer. 1996 Dec;74(11):1714-8. |
(Z)-RG-13022
CAS: 149286-90-8 F: C16H14N2O2 W: 266.29
(Z)-RG-13022 is a tyrosine kinase (TK) inhibitor, which inhibits preferentially the TK activity of the EGF receptor and
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