| Bioactivity | JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo[1][2]. | ||||||||||||
| Invitro | JQ1-TCO (10 μM; 18 h) 在 HeLa 细胞中不会诱导 BRD4 的显著降解[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> (Z)-JQ1-TCO 相关抗体: | ||||||||||||
| Formula | C31H37ClN6O3S | ||||||||||||
| Molar Mass | 609.18 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Hu Z, et al. Recent Developments in PROTAC-Mediated Protein Degradation: From Bench to Clinic. Chembiochem. 2022 Jan 19;23(2):e202100270. [2]. Tyler DS, et al. Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science. 2017 Jun 30;356(6345):1397-1401. |