| Bioactivity | (S)-Sabutoclax ((S)-BI-97C1), an optically pure apogossypol derivative, is pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (S)-Sabutoclax (Compound II) inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1, and Bfl-1 with IC50 values of 0.31, 0.32, 0.20, and 0.62 μM, respectively. (S)-Sabutoclax also potently inhibits cell growth of human prostate cancer, lung cancer, and lymphoma cell lines with EC50 values of 0.13, 0.56, and 0.049 μM, respectively. (S)-Sabutoclax can be used for the research of apoptosis-based therapies against cancer[1]. | |||||||||
| Target | IC50: 0.31 μM (Bcl-XL), 0.32 μM (Bcl-2), 0.20 μM (Mcl-1), 0.62 μM (Bfl-1); EC50: 0.13 (human prostate cancer cell lines), 0.56 (lung cancer cell lines), 0.049 μM (lymphoma cell lines). | |||||||||
| Name | (S)-Sabutoclax | |||||||||
| CAS | 1228178-73-1 | |||||||||
| Formula | C42H42N2O8S | |||||||||
| Molar Mass | 732.84 | |||||||||
| Appearance | 固体 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
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| Reference | [1]. Wei J, et al. BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J Med Chem. 2010 May 27;53(10):4166-76. |
(S)-Sabutoclax
CAS: 1228178-73-1 F: C42H42N2O8S W: 732.84
(S)-Sabutoclax ((S)-BI-97C1), an optically pure apogossypol derivative, is pan-active inhibitor of antiapoptotic B-cell
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