PeptideDB

(S)-STX-478

CAS: 2883540-91-6 F: C16H12F5N5O2 W: 401.29

(S)-STX-478 is the S-enantiomer of STX-478. STX-478 is a selective inhibitor of PI3Kα mutants, preventing metabolic dys
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Bioactivity (S)-STX-478 is the S-enantiomer of STX-478. STX-478 is a selective inhibitor of PI3Kα mutants, preventing metabolic dysfunction and demonstrating antitumor activity in xenograft mouse models with PI3Kα mutant tumors[1].
CAS 2883540-91-6
Formula C16H12F5N5O2
Molar Mass 401.29
Transport Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Reference [1]. Buckbinder L, et al. STX-478, a mutant-selective, allosteric PI3Kα inhibitor spares metabolic dysfunction and improves therapeutic response in PI3Kα-mutant xenografts[J]. Cancer Discovery, 2023, 13(11): 2432-2447.