| Bioactivity | (S)-PF-04449613 is the left-handed isomer of PF-04449613 (HY-12788). PF-04449613 is a selective PDE9A inhibitor with an IC50 of 22 nM. PF-04449613 improves motor learning ability in a mouse model[1][2]. | ||||||||||||
| Target | IC50: 22 nM (PDE9A) | ||||||||||||
| Name | (S)-PF-04449613 | ||||||||||||
| Formula | C21H25N5O3 | ||||||||||||
| Molar Mass | 395.45 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Claffey MM, et al. Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. J Med Chem. 2012 Nov 8;55(21):9055-68. [2]. Lai B, et al. The Phosphodiesterase 9 Inhibitor PF-04449613 Promotes Dendritic Spine Formation and Performance Improvement after Motor Learning. Dev Neurobiol. 2018 Sep;78(9):859-872. |