(S)-Lansoprazole_product_DataBase

Bioactivity	(S)-Lansoprazole (Levolansoprazole) is an isoform of Lansoprazole (HY-13662), which is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[1][2].
Invitro	0.3 至 3 μM 的 Lansoprazole 以浓度依赖性方式抑制胃酸形成（IC50 为 0.76 μM）[4]。Lansoprazole(30-300 μM) 均可诱导浓度依赖性、可逆且可重复的动脉松弛[5]。 0 --> (S)-Lansoprazole 相关抗体:
In Vivo	Lansoprazole (20-40 mg/kg) 处理可显着减轻 STZ 和 HFD 引起的记忆缺陷、生化和组织病理学改变[3]。？Lansoprazole（20 mg/kg 和 40 mg/kg，口服）显着降低 STZ 和 HFD 诱导的 AChE 活性增加[3]。？Lansoprazole（20 mg/kg 和 40 mg/kg，口服）可显着降低 STZ 和 HFD 引起的脑 MPO 水平升高[3]。？另外，用 Lansoprazole（20 mg/kg 和 40 mg/kg，口服）处理的 HFD 小鼠与对照动物相比，体重显着下降[3]。
Name	(S)-Lansoprazole
CAS	138530-95-7
Formula	C16H14F3N3O2S
Molar Mass	369.36
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kokufu, T., et al., Effects of lansoprazole on pharmacokinetics and metabolism of theophylline. Eur J Clin Pharmacol, 1995. 48(5): p. 391-5. [2]. Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330. [3]. Rupinder K Sodhi, et al. Defensive effect of lansoprazole in dementia of AD type in mice exposed to streptozotocin and cholesterol enriched diet. PLoS One. 2013 Jul 31;8(7):e70487. [4]. Jun Matsukawa, et al. A comparative study on the modes of action of TAK-438, a novel potassium-competitive acid blocker, and lansoprazole in primary cultured rabbit gastric glands. Biochem Pharmacol. 2011 May 1;81(9):1145-51. [5]. Erdinc Naseri, et al. Proton pump inhibitors omeprazole and lansoprazole induce relaxation of isolated human arteries. Eur J Pharmacol. 2006 Feb 15;531(1-3):226-31.

PeptideDB

(S)-Lansoprazole

CAS: 138530-95-7 F: C16H14F3N3O2S W: 369.36