| Bioactivity | (S)-GSK-3685032 is the inactive isomer of GSK-3685032 (HY-139664), and can be used as an experimental control. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition[1]. |
| Name | (S)-GSK-3685032 |
| CAS | 2170142-58-0 |
| Formula | C22H24N6OS |
| Molar Mass | 420.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pappalardi MB, et al. Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer. 2021;2(10):1002-1017. |
(S)-GSK-3685032
CAS: 2170142-58-0 F: C22H24N6OS W: 420.53
(S)-GSK-3685032 is the inactive isomer of GSK-3685032 (HY-139664), and can be used as an experimental control. GSK-36850
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