(S)-Crizotinib_product_DataBase

CAS: 1374356-45-2 F: C21H22Cl2FN5O W: 450.34

(S)-Crizotinib is a potent and selective MTH1 (mutT homologue) inhibitor with an IC50 of 330 nM. (S)-Crizotinib disrupts

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity

(S)-Crizotinib is a potent and selective MTH1 (mutT homologue) inhibitor with an IC50 of 330 nM. (S)-Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single strand breaks, activates DNA repair in human colon carcinoma cells, and effectively suppresses tumour growth in animal models[1].

Invitro

(S)-crizotinib (0.625-80 μM; 24 hours) 降低了 NCI-H460，H1975 和 A549 细胞的活力，IC50 值分别为 14.29、16.54 和 11.25 μM[2]。(S)-crizotinib (10-30 μM; 24 hours) 诱导 NCI-H460，H1975 和 A549 细胞凋亡[2]。 (S)-crizotinib (10-30 μM; 24 hour Cell Viability Assay[2] Cell Line:

Name

(S)-Crizotinib

CAS

1374356-45-2

Formula

C21H22Cl2FN5O

Molar Mass

450.34

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

PeptideDB

(S)-Crizotinib

CAS: 1374356-45-2 F: C21H22Cl2FN5O W: 450.34