| Bioactivity | (S)-CCG-1423 is an inhibitor of Rho signaling that blocks the nuclear import of MRTF-A. (S)-CCG-1423 reduces the nuclear accumulation of MRTF-A and improves glucose uptake and tolerance in insulin-resistance mice in vivo. (S)-CCG-1423 exhibits higher inhibition activity than the SR- and the R-isomers of CCG-1423 (HY-13991). (S)-CCG-1423 can be used for the research of cancer and diabetes[1]. |
| Name | (S)-CCG-1423 |
| CAS | 2319939-24-5 |
| Formula | C18H13ClF6N2O3 |
| Molar Mass | 454.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Watanabe B, et al. Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A. PLoS One. 2015 Aug 21;10(8):e0136242. |
(S)-CCG-1423
CAS: 2319939-24-5 F: C18H13ClF6N2O3 W: 454.75
(S)-CCG-1423 is an inhibitor of Rho signaling that blocks the nuclear import of MRTF-A. (S)-CCG-1423 reduces the nuclear
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