| Bioactivity | (S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment[1][2][3][4]. |
| Invitro | (S)-10-Hydroxycamptothecin (5-20 µg/L; 6 days; Hep G2 cells) treatment results in the cell cycle arrest at G2/M phase[2].(S)-10-Hydroxycamptothecin induces differentiation, down-regulates nuclear antigen (PCNA) and up-regulates wild-type protein p53 in Hep G2 cells[2].(S)-10-Hydroxycamptothecin inhibits L1210 leukemia cells with an IC50 of 1.15 µM[1]. Cell Cycle Analysis[2] Cell Line: |
| Name | (S)-10-Hydroxycamptothecin |
| CAS | 19685-09-7 |
| Formula | C20H16N2O5 |
| Molar Mass | 364.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
(S)-10-Hydroxycamptothecin
CAS: 19685-09-7 F: C20H16N2O5 W: 364.35
(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chin
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